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Evergraf 0.5mg tablet: Uses, Dosage, Precautions – Medatdoorstep

Evergraf 0.5mg consist of an active ingredient known as Everolimus which is intruded with the growth of cancer cell and the process is slowed down. Evergraf 0.5mg tablets are not a curable medication, which helps to slow their spreading into the body. If you need Online Medicine in Dehradun so you can contact Medatdoorstep

MECHANISM OF ACTION:
Everolimus is an associate matter of mTOR, joins at high compatibility to FK506 binding protein 12, via producing drug complex that inhibits the production of mTOR.
This inhibition reduces the activity of effectors downstream, which can result in stoppage of cell progression from G1 into S Section, finally causes cell growth arrest and caspase-mediated cell death

INDICATION
Primarily Evergraf 0.5mg tablets indicated for the treatment
kidney carcinoma
Breast carcinoma
Brain carcinoma
Everolimus is additionally indicated in numerous advanced-stage cancer in abdomen, intestines or pancreas.

DOSAGE
Evergraf 0.5mg tablets should be taken with or without food.
The dosage regimen of Evergraf 0.5mg;
In breast cancer, renal cell cancer, pancreatic cancer, Neuroendocrine cancer:
The prescribed indefinite quantity is 10mg ought to be taken as one dose.
In Brain or intracranial cancer:
The prescribed indefinite quantity of Evergraf as one dose is 4.5mg/m2 given orally
In pediatric:
The pediatric dosage of Evergraf as a single dose in the brain or intracranial tumor is 4.5mg/m2 should be given orally.

PRECAUTIONS
Lymphomas:
The developed hazard of skin cancers, the patient may protect from UV light

Serious infections:
Patients getting Evergraf 0.5mg have a severe risk of achieving various infections related to bacteria, virus, and fungi.

Hepatic artery thrombosis:
Evergraf 0.5mg therapy should not be recommended in liver transplant patients,

Nephrotoxicity :
While using Evergraf 0.5mg in renal impaired patient’s renal function should be monitored frequently; drug use with caution.

DRUG INTERACTION
Evergraf 0.5mg interaction with strong inhibitor of CYP3A4, P-g p, cause reducing the efflux of Everolimus and high plasma concentration of Everolimus.
Interaction of Evergraf 0.5mg with strong CYP3A4 inducers will be increasing the disclosure of Everolimus.
Combination of Evergraf 0.5mg with cyclosporine will increase the AUC level of Everolimus frequently.
Combination ketoconazole with Evergraf 0.5mg tablet or other CYP3A4 inhibitors will increase the plasma concentration and AUC of Everolimus.

PREGNANCY
Pregnancy category of Everolimus C
In patients, Evergraf 0.5mg is used only after knowing the benefits to the mother exceed the risk to the fetus.

LACTATION
Breastfeeding should not be suggested

STORAGE
Evergraf 0.5mg tablet store at 25°C.
Store the drug far from wet, heat, and light

MISSED DOSE
Whenever a patient missed a dose, the patient must consult with a medical practitioner and follow the instructions given by them.
So that the missed dose should be avoided and follow your regular dose as before.
You can contact Medatdoorstep for Online Medicine Delivery in Dehradun and for more information email us at [email protected]

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